Brentuximab vedotin or physician's choice in CD30-positive cutaneous T-cell lymphoma (ALCANZA): an international, open-label, randomised, phase 3, multicentre trial.
Identifieur interne : 001078 ( Main/Exploration ); précédent : 001077; suivant : 001079Brentuximab vedotin or physician's choice in CD30-positive cutaneous T-cell lymphoma (ALCANZA): an international, open-label, randomised, phase 3, multicentre trial.
Auteurs : H Miles Prince [Australie] ; Youn H. Kim [États-Unis] ; Steven M. Horwitz [États-Unis] ; Reinhard Dummer [Suisse] ; Julia Scarisbrick [Royaume-Uni] ; Pietro Quaglino [Italie] ; Pier Luigi Zinzani [Italie] ; Pascal Wolter [Belgique] ; Jose A. Sanches [Brésil] ; Pablo L. Ortiz-Romero [Espagne] ; Oleg E. Akilov [États-Unis] ; Larisa Geskin [États-Unis] ; Judith Trotman [Australie] ; Kerry Taylor [Australie] ; Stephane Dalle [France] ; Michael Weichenthal [Allemagne] ; Jan Walewski [Pologne] ; David Fisher [États-Unis] ; Brigitte Dréno [France] ; Rudolf Stadler [Allemagne] ; Tatyana Feldman [États-Unis] ; Timothy M. Kuzel [États-Unis] ; Yinghui Wang [États-Unis] ; Maria Corinna Palanca-Wessels [États-Unis] ; Erin Zagadailov [États-Unis] ; William L. Trepicchio [États-Unis] ; Wenwen Zhang [États-Unis] ; Hui-Min Lin [États-Unis] ; Yi Liu [États-Unis] ; Dirk Huebner [États-Unis] ; Meredith Little [États-Unis] ; Sean Whittaker [Royaume-Uni] ; Madeleine Duvic [États-Unis]Source :
- Lancet (London, England) [ 1474-547X ] ; 2017.
Abstract
Cutaneous T-cell lymphomas are rare, generally incurable, and associated with reduced quality of life. Present systemic therapies rarely provide reliable and durable responses. We aimed to assess efficacy and safety of brentuximab vedotin versus conventional therapy for previously treated patients with CD30-positive cutaneous T-cell lymphomas.
DOI: 10.1016/S0140-6736(17)31266-7
PubMed: 28600132
Affiliations:
- Allemagne, Australie, Belgique, Brésil, Espagne, France, Italie, Pologne, Royaume-Uni, Suisse, États-Unis
- Angleterre, Auvergne-Rhône-Alpes, Californie, Communauté de Madrid, Grand Londres, Illinois, Massachusetts, Midlands de l'Ouest, New Jersey, Nouvelle-Galles du Sud, Pays de la Loire, Pennsylvanie, Piémont, Rhône-Alpes, Schleswig-Holstein, Texas, Victoria (État), Washington (État), État de New York, État de São Paulo
- Birmingham, Kiel, Londres, Lyon, Madrid, Melbourne, Nantes, Pittsburgh, Sydney, São Paulo, Turin
- Université de Melbourne, Université de Pittsburgh, Université de Sydney
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Trepicchio</name><affiliation wicri:level="2"><nlm:affiliation>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Zhang, Wenwen" sort="Zhang, Wenwen" uniqKey="Zhang W" first="Wenwen" last="Zhang">Wenwen Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lin, Hui Min" sort="Lin, Hui Min" uniqKey="Lin H" first="Hui-Min" last="Lin">Hui-Min Lin</name><affiliation wicri:level="2"><nlm:affiliation>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Liu, Yi" sort="Liu, Yi" uniqKey="Liu Y" first="Yi" last="Liu">Yi Liu</name><affiliation wicri:level="2"><nlm:affiliation>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Huebner, Dirk" 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Electronic address: Miles.Prince@petermac.org.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Division of Cancer Medicine, Peter MacCallum Cancer Centre, The University of Melbourne, Melbourne, VIC, Australia; Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, VIC, Australia; Epworth Healthcare, The University of Melbourne, Melbourne, VIC</wicri:regionArea><orgName type="university">Université de Melbourne</orgName><placeName><settlement type="city">Melbourne</settlement><region type="état">Victoria (État)</region></placeName></affiliation></author><author><name sortKey="Kim, Youn H" sort="Kim, Youn H" uniqKey="Kim Y" first="Youn H" last="Kim">Youn H. Kim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Horwitz, Steven M" sort="Horwitz, Steven M" uniqKey="Horwitz S" first="Steven M" last="Horwitz">Steven M. Horwitz</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Dummer, Reinhard" sort="Dummer, Reinhard" uniqKey="Dummer R" first="Reinhard" last="Dummer">Reinhard Dummer</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dermatology, University Hospital Zurich, Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Department of Dermatology, University Hospital Zurich, Zurich</wicri:regionArea><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Scarisbrick, Julia" sort="Scarisbrick, Julia" uniqKey="Scarisbrick J" first="Julia" last="Scarisbrick">Julia Scarisbrick</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Hospital Birmingham, Birmingham, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Dermatology, University Hospital Birmingham, Birmingham</wicri:regionArea><placeName><settlement type="city">Birmingham</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Midlands de l'Ouest</region></placeName></affiliation></author><author><name sortKey="Quaglino, Pietro" sort="Quaglino, Pietro" uniqKey="Quaglino P" first="Pietro" last="Quaglino">Pietro Quaglino</name><affiliation wicri:level="3"><nlm:affiliation>Department of Medical Sciences, Dermatologic Clinic, University of Turin, Turin, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Department of Medical Sciences, Dermatologic Clinic, University of Turin, Turin</wicri:regionArea><placeName><settlement type="city">Turin</settlement><region type="région" nuts="2">Piémont</region></placeName></affiliation></author><author><name sortKey="Zinzani, Pier Luigi" sort="Zinzani, Pier Luigi" uniqKey="Zinzani P" first="Pier Luigi" last="Zinzani">Pier Luigi Zinzani</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Haematology, University of Bologna, Bologna, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Haematology, University of Bologna, Bologna</wicri:regionArea><wicri:noRegion>Bologna</wicri:noRegion></affiliation></author><author><name sortKey="Wolter, Pascal" sort="Wolter, Pascal" uniqKey="Wolter P" first="Pascal" last="Wolter">Pascal Wolter</name><affiliation wicri:level="1"><nlm:affiliation>Department of General Medical Oncology, University Hospitals Leuven, Leuven, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Department of General Medical Oncology, University Hospitals Leuven, Leuven</wicri:regionArea><wicri:noRegion>Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Sanches, Jose A" sort="Sanches, Jose A" uniqKey="Sanches J" first="Jose A" last="Sanches">Jose A. Sanches</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University of São Paulo Medical School, São Paulo, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Department of Dermatology, University of São Paulo Medical School, São Paulo</wicri:regionArea><placeName><settlement type="city">São Paulo</settlement><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Ortiz Romero, Pablo L" sort="Ortiz Romero, Pablo L" uniqKey="Ortiz Romero P" first="Pablo L" last="Ortiz-Romero">Pablo L. Ortiz-Romero</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Hospital 12 de Octubre, Institute i+12 Medical School, University Complutense, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Department of Dermatology, University Hospital 12 de Octubre, Institute i+12 Medical School, University Complutense, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Akilov, Oleg E" sort="Akilov, Oleg E" uniqKey="Akilov O" first="Oleg E" last="Akilov">Oleg E. Akilov</name><affiliation wicri:level="4"><nlm:affiliation>Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, University of Pittsburgh, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Geskin, Larisa" sort="Geskin, Larisa" uniqKey="Geskin L" first="Larisa" last="Geskin">Larisa Geskin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Dermatology, Columbia University, New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, University of Pittsburgh, Pittsburgh, PA, USA; Department of Dermatology, Columbia University, New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region><settlement type="city">Pittsburgh</settlement></placeName><orgName type="university">Université de Pittsburgh</orgName></affiliation></author><author><name sortKey="Trotman, Judith" sort="Trotman, Judith" uniqKey="Trotman J" first="Judith" last="Trotman">Judith Trotman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Haematology, Concord Repatriation General Hospital, University of Sydney, Concord, NSW, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Department of Haematology, Concord Repatriation General Hospital, University of Sydney, Concord, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Taylor, Kerry" sort="Taylor, Kerry" uniqKey="Taylor K" first="Kerry" last="Taylor">Kerry Taylor</name><affiliation wicri:level="1"><nlm:affiliation>ICON Cancer Care, South Brisbane, QLD, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>ICON Cancer Care, South Brisbane, QLD</wicri:regionArea><wicri:noRegion>QLD</wicri:noRegion></affiliation></author><author><name sortKey="Dalle, Stephane" sort="Dalle, Stephane" uniqKey="Dalle S" first="Stephane" last="Dalle">Stephane Dalle</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Dermatology, Hospices Civils de Lyon, Claude Bernard Lyon 1 University, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Weichenthal, Michael" sort="Weichenthal, Michael" uniqKey="Weichenthal M" first="Michael" last="Weichenthal">Michael Weichenthal</name><affiliation wicri:level="3"><nlm:affiliation>Department of Dermatology, University Hospital of Schleswig-Holstein, Kiel, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Dermatology, University Hospital of Schleswig-Holstein, Kiel</wicri:regionArea><placeName><region type="land" nuts="2">Schleswig-Holstein</region><settlement type="city">Kiel</settlement></placeName></affiliation></author><author><name sortKey="Walewski, Jan" sort="Walewski, Jan" uniqKey="Walewski J" first="Jan" last="Walewski">Jan Walewski</name><affiliation wicri:level="1"><nlm:affiliation>Maria Sklodowska-Curie Institute and Oncology Centre, Warsaw, Poland.</nlm:affiliation><country xml:lang="fr">Pologne</country><wicri:regionArea>Maria Sklodowska-Curie Institute and Oncology Centre, Warsaw</wicri:regionArea><wicri:noRegion>Warsaw</wicri:noRegion></affiliation></author><author><name sortKey="Fisher, David" sort="Fisher, David" uniqKey="Fisher D" first="David" last="Fisher">David Fisher</name><affiliation wicri:level="2"><nlm:affiliation>Dana-Farber Cancer Institute, Boston, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Dana-Farber Cancer Institute, Boston, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dréno">Brigitte Dréno</name><affiliation wicri:level="3"><nlm:affiliation>Faculty of Medicine, Nantes University, Nantes, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Faculty of Medicine, Nantes University, Nantes</wicri:regionArea><placeName><region type="region">Pays de la Loire</region><region type="old region">Pays de la Loire</region><settlement type="city">Nantes</settlement></placeName></affiliation></author><author><name sortKey="Stadler, Rudolf" sort="Stadler, Rudolf" uniqKey="Stadler R" first="Rudolf" last="Stadler">Rudolf Stadler</name><affiliation wicri:level="1"><nlm:affiliation>University Clinic for Dermatology, Johannes Wesling Medical Centre, Minden, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>University Clinic for Dermatology, Johannes Wesling Medical Centre, Minden</wicri:regionArea><wicri:noRegion>Minden</wicri:noRegion><wicri:noRegion>Minden</wicri:noRegion><wicri:noRegion>Minden</wicri:noRegion></affiliation></author><author><name sortKey="Feldman, Tatyana" sort="Feldman, Tatyana" uniqKey="Feldman T" first="Tatyana" last="Feldman">Tatyana Feldman</name><affiliation wicri:level="2"><nlm:affiliation>John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>John Theurer Cancer Center at Hackensack University Medical Center, Hackensack, NJ</wicri:regionArea><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Kuzel, Timothy M" sort="Kuzel, Timothy M" uniqKey="Kuzel T" first="Timothy M" last="Kuzel">Timothy M. Kuzel</name><affiliation wicri:level="2"><nlm:affiliation>Division of Hematology/Oncology/Cell Therapy, Department of Medicine, Rush University, Chicago, IL, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Hematology/Oncology/Cell Therapy, Department of Medicine, Rush University, Chicago, IL</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Wang, Yinghui" sort="Wang, Yinghui" uniqKey="Wang Y" first="Yinghui" last="Wang">Yinghui Wang</name><affiliation wicri:level="2"><nlm:affiliation>Seattle Genetics Inc, Bothell, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Seattle Genetics Inc, Bothell, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Palanca Wessels, Maria Corinna" sort="Palanca Wessels, Maria Corinna" uniqKey="Palanca Wessels M" first="Maria Corinna" last="Palanca-Wessels">Maria Corinna Palanca-Wessels</name><affiliation wicri:level="2"><nlm:affiliation>Seattle Genetics Inc, Bothell, WA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Seattle Genetics Inc, Bothell, WA</wicri:regionArea><placeName><region type="state">Washington (État)</region></placeName></affiliation></author><author><name sortKey="Zagadailov, Erin" sort="Zagadailov, Erin" uniqKey="Zagadailov E" first="Erin" last="Zagadailov">Erin Zagadailov</name><affiliation wicri:level="2"><nlm:affiliation>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Trepicchio, William L" sort="Trepicchio, William L" uniqKey="Trepicchio W" first="William L" last="Trepicchio">William L. Trepicchio</name><affiliation wicri:level="2"><nlm:affiliation>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Zhang, Wenwen" sort="Zhang, Wenwen" uniqKey="Zhang W" first="Wenwen" last="Zhang">Wenwen Zhang</name><affiliation wicri:level="2"><nlm:affiliation>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Lin, Hui Min" sort="Lin, Hui Min" uniqKey="Lin H" first="Hui-Min" last="Lin">Hui-Min Lin</name><affiliation wicri:level="2"><nlm:affiliation>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Liu, Yi" sort="Liu, Yi" uniqKey="Liu Y" first="Yi" last="Liu">Yi Liu</name><affiliation wicri:level="2"><nlm:affiliation>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Huebner, Dirk" sort="Huebner, Dirk" uniqKey="Huebner D" first="Dirk" last="Huebner">Dirk Huebner</name><affiliation wicri:level="2"><nlm:affiliation>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Little, Meredith" sort="Little, Meredith" uniqKey="Little M" first="Meredith" last="Little">Meredith Little</name><affiliation wicri:level="2"><nlm:affiliation>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Millennium Pharmaceuticals Inc, Takeda Pharmaceutical Company Ltd, Cambridge, MA</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Whittaker, Sean" sort="Whittaker, Sean" uniqKey="Whittaker S" first="Sean" last="Whittaker">Sean Whittaker</name><affiliation wicri:level="3"><nlm:affiliation>St John's Institute of Dermatology, Guys and St Thomas NHS Foundation Trust, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>St John's Institute of Dermatology, Guys and St Thomas NHS Foundation Trust, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Duvic, Madeleine" sort="Duvic, Madeleine" uniqKey="Duvic M" first="Madeleine" last="Duvic">Madeleine Duvic</name><affiliation wicri:level="2"><nlm:affiliation>The University of Texas MD Anderson Cancer Center, Houston, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>The University of Texas MD Anderson Cancer Center, Houston, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author></analytic><series><title level="j">Lancet (London, England)</title><idno type="eISSN">1474-547X</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cutaneous T-cell lymphomas are rare, generally incurable, and associated with reduced quality of life. Present systemic therapies rarely provide reliable and durable responses. We aimed to assess efficacy and safety of brentuximab vedotin versus conventional therapy for previously treated patients with CD30-positive cutaneous T-cell lymphomas.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Belgique</li><li>Brésil</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pologne</li><li>Royaume-Uni</li><li>Suisse</li><li>États-Unis</li></country><region><li>Angleterre</li><li>Auvergne-Rhône-Alpes</li><li>Californie</li><li>Communauté de Madrid</li><li>Grand Londres</li><li>Illinois</li><li>Massachusetts</li><li>Midlands de l'Ouest</li><li>New Jersey</li><li>Nouvelle-Galles du Sud</li><li>Pays de la Loire</li><li>Pennsylvanie</li><li>Piémont</li><li>Rhône-Alpes</li><li>Schleswig-Holstein</li><li>Texas</li><li>Victoria (État)</li><li>Washington (État)</li><li>État de New York</li><li>État de São Paulo</li></region><settlement><li>Birmingham</li><li>Kiel</li><li>Londres</li><li>Lyon</li><li>Madrid</li><li>Melbourne</li><li>Nantes</li><li>Pittsburgh</li><li>Sydney</li><li>São Paulo</li><li>Turin</li></settlement><orgName><li>Université de Melbourne</li><li>Université de Pittsburgh</li><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Prince, H Miles" sort="Prince, H Miles" uniqKey="Prince H" first="H Miles" last="Prince">H Miles Prince</name></region><name sortKey="Taylor, Kerry" sort="Taylor, Kerry" uniqKey="Taylor K" first="Kerry" last="Taylor">Kerry Taylor</name><name sortKey="Trotman, Judith" sort="Trotman, Judith" uniqKey="Trotman J" first="Judith" last="Trotman">Judith Trotman</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Kim, Youn H" sort="Kim, Youn H" uniqKey="Kim Y" first="Youn H" last="Kim">Youn H. Kim</name></region><name sortKey="Akilov, Oleg E" sort="Akilov, Oleg E" uniqKey="Akilov O" first="Oleg E" last="Akilov">Oleg E. Akilov</name><name sortKey="Duvic, Madeleine" sort="Duvic, Madeleine" uniqKey="Duvic M" first="Madeleine" last="Duvic">Madeleine Duvic</name><name sortKey="Feldman, Tatyana" sort="Feldman, Tatyana" uniqKey="Feldman T" first="Tatyana" last="Feldman">Tatyana Feldman</name><name sortKey="Fisher, David" sort="Fisher, David" uniqKey="Fisher D" first="David" last="Fisher">David Fisher</name><name sortKey="Geskin, Larisa" sort="Geskin, Larisa" uniqKey="Geskin L" first="Larisa" last="Geskin">Larisa Geskin</name><name sortKey="Horwitz, Steven M" sort="Horwitz, Steven M" uniqKey="Horwitz S" first="Steven M" last="Horwitz">Steven M. Horwitz</name><name sortKey="Huebner, Dirk" sort="Huebner, Dirk" uniqKey="Huebner D" first="Dirk" last="Huebner">Dirk Huebner</name><name sortKey="Kuzel, Timothy M" sort="Kuzel, Timothy M" uniqKey="Kuzel T" first="Timothy M" last="Kuzel">Timothy M. Kuzel</name><name sortKey="Lin, Hui Min" sort="Lin, Hui Min" uniqKey="Lin H" first="Hui-Min" last="Lin">Hui-Min Lin</name><name sortKey="Little, Meredith" sort="Little, Meredith" uniqKey="Little M" first="Meredith" last="Little">Meredith Little</name><name sortKey="Liu, Yi" sort="Liu, Yi" uniqKey="Liu Y" first="Yi" last="Liu">Yi Liu</name><name sortKey="Palanca Wessels, Maria Corinna" sort="Palanca Wessels, Maria Corinna" uniqKey="Palanca Wessels M" first="Maria Corinna" last="Palanca-Wessels">Maria Corinna Palanca-Wessels</name><name sortKey="Trepicchio, William L" sort="Trepicchio, William L" uniqKey="Trepicchio W" first="William L" last="Trepicchio">William L. Trepicchio</name><name sortKey="Wang, Yinghui" sort="Wang, Yinghui" uniqKey="Wang Y" first="Yinghui" last="Wang">Yinghui Wang</name><name sortKey="Zagadailov, Erin" sort="Zagadailov, Erin" uniqKey="Zagadailov E" first="Erin" last="Zagadailov">Erin Zagadailov</name><name sortKey="Zhang, Wenwen" sort="Zhang, Wenwen" uniqKey="Zhang W" first="Wenwen" last="Zhang">Wenwen Zhang</name></country><country name="Suisse"><noRegion><name sortKey="Dummer, Reinhard" sort="Dummer, Reinhard" uniqKey="Dummer R" first="Reinhard" last="Dummer">Reinhard Dummer</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Scarisbrick, Julia" sort="Scarisbrick, Julia" uniqKey="Scarisbrick J" first="Julia" last="Scarisbrick">Julia Scarisbrick</name></region><name sortKey="Whittaker, Sean" sort="Whittaker, Sean" uniqKey="Whittaker S" first="Sean" last="Whittaker">Sean Whittaker</name></country><country name="Italie"><region name="Piémont"><name sortKey="Quaglino, Pietro" sort="Quaglino, Pietro" uniqKey="Quaglino P" first="Pietro" last="Quaglino">Pietro Quaglino</name></region><name sortKey="Zinzani, Pier Luigi" sort="Zinzani, Pier Luigi" uniqKey="Zinzani P" first="Pier Luigi" last="Zinzani">Pier Luigi Zinzani</name></country><country name="Belgique"><noRegion><name sortKey="Wolter, Pascal" sort="Wolter, Pascal" uniqKey="Wolter P" first="Pascal" last="Wolter">Pascal Wolter</name></noRegion></country><country name="Brésil"><region name="État de São Paulo"><name sortKey="Sanches, Jose A" sort="Sanches, Jose A" uniqKey="Sanches J" first="Jose A" last="Sanches">Jose A. Sanches</name></region></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Ortiz Romero, Pablo L" sort="Ortiz Romero, Pablo L" uniqKey="Ortiz Romero P" first="Pablo L" last="Ortiz-Romero">Pablo L. Ortiz-Romero</name></region></country><country name="France"><region name="Auvergne-Rhône-Alpes"><name sortKey="Dalle, Stephane" sort="Dalle, Stephane" uniqKey="Dalle S" first="Stephane" last="Dalle">Stephane Dalle</name></region><name sortKey="Dreno, Brigitte" sort="Dreno, Brigitte" uniqKey="Dreno B" first="Brigitte" last="Dréno">Brigitte Dréno</name></country><country name="Allemagne"><region name="Schleswig-Holstein"><name sortKey="Weichenthal, Michael" sort="Weichenthal, Michael" uniqKey="Weichenthal M" first="Michael" last="Weichenthal">Michael Weichenthal</name></region><name sortKey="Stadler, Rudolf" sort="Stadler, Rudolf" uniqKey="Stadler R" first="Rudolf" last="Stadler">Rudolf Stadler</name></country><country name="Pologne"><noRegion><name sortKey="Walewski, Jan" sort="Walewski, Jan" uniqKey="Walewski J" first="Jan" last="Walewski">Jan Walewski</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:28600132" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a AustralieFrV1
| This area was generated with Dilib version V0.6.33. |  |